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1995-07-29
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Path: bloom-beacon.mit.edu!spool.mu.edu!uwm.edu!lll-winken.llnl.gov!overload.lbl.gov!acedbfaq
From: acedbfaq@s27w007.pswfs.gov (ACEDB FAQ Pseudouser)
Newsgroups: bionet.software.acedb,news.answers
Subject: ACEDB Genome Database Software FAQ
Followup-To: bionet.software.acedb
Date: 14 Nov 1994 22:17:29 GMT
Organization: Dendrome, A genome database for forest trees
Lines: 1124
Approved: news-answers-request@MIT.Edu
Message-ID: <3a8nlp$ee6@overload.lbl.gov>
Reply-To: acedbfaq@s27w007.pswfs.gov
NNTP-Posting-Host: s27w007.pswfs.gov
Summary: Frequently Asked Questions about finding and getting
started with the database system ACEDB. ACEDB is used
to collect information regarding the molecular biology
of the genome.
Xref: bloom-beacon.mit.edu bionet.software.acedb:437 news.answers:29377
Archive-name: acedb-faq
Last-modified: 11/14/94
Version: 1.16
----------------------------------------------------------------------
Common Questions, with Answers, about ACEDB.
Q0: What is ACEDB?
Q1: What is the current version of ACEDB?
Q2: What hardware/software do I need to run ACEDB?
Q3: Where can I get ACEDB?
!Q4: What ACEDB databases exist?
Q5: What written documentation exists for ACEDB?
Q6: Where can I find further information about ACEDB?
Q7: How should ACEDB be cited?
Q8: Is ACEDB object-oriented?
Q9: What's all this about Gopher|WAIS|ftp|WWW|URL ...
Q10: How can I get on/off the ACEDB announcements mailing list?
Q11: When and where is the next ACEDB Workshop?
Q411: Who prepared this document & where is the current version?
Questions marked with + are new, those with !
have substantially changed answers.
----------------------------------------------------------------------
Q0: What is ACEDB?
A0: ACEDB is an acronym for A Caenorhabditis elegans Database. It can
refer to a database and data concerning the nematode C. elegans,
or to the database software alone. This document is concerned
primarily with the latter meaning. ACEDB is being adapted by many
groups to organize molecular biology data about the genomes of
diverse species [see Q4].
ACEDB allows for automatic cross-referencing of items during
loading and allows for hypertextual navigation of the links
using a graphical user interface and mouse. Certain special
purpose graphical displays have been integrated into the
software. These reflect the needs of molecular biologists
in constructing genetic and physical maps of genomes.
ACEDB was written and developed by Richard Durbin (MRC LMB
Cambridge, England) and Jean Thierry-Mieg (CNRS, Montpellier,
France), beginning circa 1990. It is written in the C programming
language and uses the X11 windowing system to provide a platform
independent graphical user interface. The source code is publicly
available [See Q3]. Durbin & Thierry-Mieg continue to develop
the system, with contributions from other groups including
Lawrence Berkeley Laboratory and the European integrated Genome
Project.
A description by Durbin & Thierry-Mieg:
ACEDB does not use an underlying relational database
schema, but a system we wrote ourselves in which data
are stored in objects that belong in classes. This is
nevertheless a general database management system using
caches, session control, and a powerful query language.
Typical objects are clones, genes, alleles, papers,
sequences, etc. Each object is stored as a tree,
following a hierarchical structure for the class (called
the "model"). Maps are derived from data stored in tree
objects, but precomputed and stored as tables for
efficiency. The system of models allows flexibility
and efficiency of storage -missing data are not stored.
A major advantage is that the models can be extended
and refined without invalidating an existing database.
Comments can be added to any node of an object.
Return to List of Questions
----------------------------------------------------------------------
Q1: What is the current version of ACEDB?
A1: [This answer refers to the software not the C. elegans data.]
Currently there are two threads of the ACEDB kernel: the
2.x series which represents the C. elegans project under
the tutelage of Richard Durbin, and the 3.x series from
Jean Thierry-Mieg. However, the differences in the code
are slight and the two authors committed to a single
kernel at the ACEDB workshop in July, 1994. The most
recent release is an experimental version 3.3 which
is available from the repositories.
A Macintosh version is available as version 2.0b4.
To retrieve the software see Q3.
To be kept informed of new releases see Q10.
Return to List of Questions
----------------------------------------------------------------------
Q2: What hardware/software do I need to run ACEDB?
A2:
Unix and X11:
Sun/SunOS 4.x
Sun/Solaris
DEC DECstation3100, 5100 etc.
DEC Alpha/OSF-1
Silicon Graphics Iris series
PC 386/486 with Linux (free Unix)
[note from Jeff Bryer, jbryer@darwin.mbb.sfu.ca]
I just installed up Linux yesterday and today spent
the many hours to compile in the C. elegans data for
ACEDB v2.0 So to save other people the trouble of
doing the same the entire package ACEDB for Linux 2-10
is available on trog.mbb.sfu.ca in /pub/acedb as
linux.2_10.tar.Z
The data was compiled in on a 486DX-33 with 16MBs of
RAM running Linux 1.1.18 (Slackware 2.0.0 distribution)
and a 32MB swap device (and it chugged away for a couple
hours chewing up all 16MBs and half the swap space).
File size is about 73MBs uncompressed, 26MBs compressed.
This is based on the ACEDB v2.0 port for Linux that Ken
Clark (ken@darwin.mbb.sfu.ca) did.
There exist, or have existed, ports onto Alliant, Hewlett-
Packard, IBM R6000, Convex. You may have to contact
the developer responsible for the port to make these real.
NeXT: contact Patrick Phillips at University of Texas,
NeXTmail: patrick@wbar.uta.edu
email: phil@decster.uta.edu
MSDOS/Windows/NT:
A port to NT is rumored to be in the works.
Macintosh:
[Contributed by Frank Eeckman]
Macace is distributed as a self-extracting archive that contains
the application, the wspec files, and a fully up to date
database. macace 3.0 is available with an updated 21bdb
database. Please send all questions/bug reports to
eeckman@llnl.gov A native powerPC version is available as
well. Macace needs a macintosh with > 16 MBytes of RAM,
and a decent color monitor is preferred. System 7 or
greater is required. For the multimedia extensions Quicktime
1.0 is required. Please add your name to our mailing list by
sending email to eeckman@llnl.gov.
It is our belief that for cost savings a powerPC mac will beat
the advertised linux-intel combination.
Macace is fully compatible with xace, but includes some
multimedia extensions (picture and movie support) not found
in the unix versions.
To retrieve the software see Q3.
For cost savings, a combination of a high-end Intel platform
with Linux appears very attractive. [Though the port does
not seem robust, yet --bks]
Here at the Institute of Forest Genetics we run ACEDB on a
Sun Microsystems SPARCstation II, and users can interact
using Macintoshes and PC-clones by using X11 implementations
for the personal computers and a LAN.
X11 fonts note: ACEDB uses fonts listed in the xfonts.wrm
file. If you install new fonts on your machine be sure to
run bldfamily(1) so that they are available.
Return to List of Questions
----------------------------------------------------------------------
Q3: Where can I get ACEDB?
A3: All the files are available in the following public access
accounts (anonymous ftp sites) accessible via Internet:
lirmm.lirmm.fr (193.49.104.10) in pub/acedb
cele.mrc-lmb.cam.ac.uk (131.111.84.1) in pub/acedb
ncbi.nlm.nih.gov (130.14.20.1) in repository/acedb
bioinformatics.weizmann.ac.il (132.76.55.12) in
pub/databases/acedb.
MacAce is available from:
genome.lbl.gov
(131.243.224.80) in pub/macace
cele.mrc-lmb.cam.ac.uk (131.111.84.1) in pub/acedb/macace
Linux; ACEDB version 2.0 for Linux 2-10:
trog.mbb.sfu.ca /pub/acedb as linux.2_10.tar.Z
A typical session would be:
ftp ncbi.nlm.nih.gov
login: anonymous
password: your email address
cd repository/acedb/ace3
binary
ls
get README_3
get NOTES
get INSTALL
get bin.sparc.3.0.tar.Z
quit
Return to List of Questions
----------------------------------------------------------------------
Q4: What ACEDB databases exist?
A4: [In alphabetic order by Database name.
Curators, submit changes as new paragraphs.--bks]
Database : AAnDB-1.0
Species : Aspergillus nidulans
PI : Leland Ellis
Last_update : February 1994
ACEDB_version : 3.0
Contact : leland@stralight.tamu.edu
URL : http://keck.tamu.edu/ibt.html
Comment : defunct, See AGsDB
Database : AAtDB
Species : Arabidopsis thaliana
Current version : 3-3
Last_update : June 1994
Curator : John Morris
Contact : curator@frodo.mgh.harvard.edu
Availability : ftp weeds.mgh.harvard.edu/aatdb/aatdb.3x
Availability : Macintosh version in /aatdb/MacAAtDB directory
URL : gopher://weeds.mgh.harvard.edu/
URL : http://weeds.mgh.harvard.edu:80/index.html
Database : ABtDB-1.0
Species : Bovine, Bos taurus
ACEDB_version : 3.0 extended
PI : Leland Ellis
Last_update : February 1994
Contact : leland@stralight.tamu.edu
URL : http://keck.tamu.edu/ibt.html
Comment : defunct, See AGsDB
Database : AboutDB
Curator : Staffan Bergh
PI : Staffan Bergh
Subject : ACEDB itself (Is this meta-meta-metadata)
ACEDB 3.0
Contact : staffan@biochem.kth.se
URL http://kiev.physchem.kth.se/AboutDB.html
Database : ACeDB
Species : Caenorhabditis elegans
Current version: 2-10
Curator : Jean Thierry-Mieg
Curator : Richard Durbin
Contact : rd@mrc-lmb.cam.ac.uk
Contact : mieg@kaa.crbm.cnrs-mop.fr
Last_update : May 1994
DataBase : AceMap
Species : Homo sapiens (Mus musculus under development)
Focus : Physical mapping of human chromsome X and 21
ACEDB_version : 3.0
Curator : Hugues Roest Crollius
PI : Hans Lehrach
Availability : beta release of the X chr. data/models by
anonymous ftp to
ftp.icnet.uk in icrf-public/GenomeAnalysis/X/acemap.
Get the README file in the directory above.
Contact : hrc@gea.lif.icnet.uk (Hugues Roest Crollius)
ICRF, Lincoln's Inn Fields London, UK.
Last_update : August 94
Database : AGsDB A Genus species Database
Species : Aspergillus nidulans
Species : Neurospora crassa
Species : cow w/ human anchor loci
Species : cotton (demo)
Species : Homologs of Aspergillus cell cycle loci
for budding and fission yeast
PI : Leland Ellis
Curator : Leland Ellis
Last_update : March 1994
ACeDB_version : 3.0 (beta still), with extensions to the Human
C21 Models to provide for multiple species, and queries
between species via Homologs (e.g., cell cycle loci with
links via Homologs between Aspergillus and budding
C. cerevisiae) and fission (S. pombe) yeast);
interacting loci via defined Interactions for each locus
Models : as of 3.13.94
Data : as of 3.13.94
Revision : AAnDB for Aspergillus nidulans and ABtDB for
Bos taurus (cow) have been folded into AGsDB, and are
not being developed futher as individual species databases.
WWW : WWW-AGsDB is an interface of AGsDB with the World-Wide
Web, and utilizes the WWW-ACeDB Server (nph-acedb3) of
Guy Ducoux (ducoux@moulon.inra.fr).
URL : http://keck.tamu.edu/ibt.html
Contact : leland@straylight.tamu.edu
Database : ChlamyDB
Species : Chlamydomonas
PI : Elizabeth Harris
Contact : chlamy@acpub.duke.edu
Availability : ChlamyDB 1.0, using ACEDB 3.0, is now on WWW and
gopher (probe.nalusda.gov). Complete version using ACECB
3.3 will be available soon by ftp.
URL : http://probe.nalusda.gov:8300
Last_update : 25 Oct, 1994
Database : CottonDB
Species : Gossypium hirsutum (cotton)
PI : Russell J. Kohel
USDA-ARS
Southern Crops Research Laboratory
Route 5, Box 805, College Station, Texas 77845
Curator : Gerard R. Lazo
Curator : Sridhar Madhavan
Last_update : July, 1994
ACEDB_version : 3.0
Contact : rjk0339@zeus.tamu.edu (Russell Kohel)
Contact : lazo@genome.tamu.edu (Gerard Lazo)
Availability : still under construction
Phone : 409-260-9311
Fax : 409-260-9333
Database : CSNDB
Focus : Cell Signalling Molecules and Interactions
Contact : Takako Igarashi
National Insitute of Health Sciences
Division of Chem-Bio Informatics
Setagaya-ku, Tokyo, Japan 158
taka@nihs.go.jp
Database : EcoDB
Species : E. coli
PI : Staffan Bergh
Contact : staffan@biochem.kth.se
Availability : Proposed
Last_update : Aug. 1994
Database : 11DB
Species : Homo sapiens
Focus : Physical mapping of chromosome 11
Availability : under development
Curator : Benedict Arnold
PI : Peter Little
Contact : Benedict Arnold
Dept. Biochemistry,
Imperial College,
London, SW7 2AZ
b.arnold@ic.ac.uk
Database : The Encyclopaedia of the Drosophila Genome.
Acronym : (none)
Species : Drosophilidae (primarily D. melanogaster)
Availability : MacFly/FlyDB-based distribution by ftp and CD-ROM due early 1995
Developer : Suzanna Lewis
Contact : suzi@fly2.berkeley.edu
Developer : Cyrus Harmon
Contact : sly@fly2.berkeley.edu
Developer : Edward Welbourne
Contact : eddy@gen.cam.ac.uk
Curation : Data is provided by the collaborating organisations:
Collaborator : The FlyBase Consortium, flybase@morgan.harvard.edu
Collaborator : The Berkeley Drosophila Genome Project
URL : gopher://fly.bio.indiana.edu:70+/11/Flybase
Database : Flydb
Species : Drosophila melanogaster
Curator : Suzanna Lewis
Contact : suzi@fly2.berkeley.edu
Database : GrainGenes
Species : Wheat, barley, oats, relatives
Availability : Anonymous ftp from probe.nalusda.gov:pub/grains
Availability : Gopher greengenes.cit.cornell.edu port 70
Availability : Gopher probe.nalusda.gov port 7002
Curator : David E. Matthews
PI : Olin D. Anderson
Contact : matthews@greengenes.cit.cornell.edu
Contact : oandersn@wheat.usda.gov
URL : gopher://greengenes.cit.cornell.edu/1/
Data_version : 1.3
Released : 12 Jan 1994
Based_on : acedb.1-10
Availability : See following WWW URL
URL : http://probe.nalusda.gov:8300
Last_update : Feb. 1994
Database : human.c17
Species : Homo sapiens
Availability : the database is under development
Contact : lsprilus@weizmann.weizmann.ac.il
Focus : mapping & sequencing of Human Chromosome 17
Based_on: acedb.3-0
Last_update : Jan. 1994
Database : IGD - the Integrated Genomic Database
Species : Homo sapiens (later mouse and other mammalian species)
Availability : September 1994 by ftp, on-line server October 1994
Contact : Otto Ritter [ o.ritter@dkfz-heidelberg.de ]
Curator : tba
Description : IGD - the Integrated Genomic Database -
aims to integrate multiple public general molecular
biology and human genome specific databases into single
logical database with unified interface to existing
analysis tools.
Database : LIGM-DB
Curator : Veronique Giudicelli
Focus : genetic and physical mapping of loci of Immunoglobulins and
Tcell receptors
PI : Marie_paule Lefranc
Contact : Veronique Giudicelli
LIGM IGMM UMR CNRS 9942
BP 5051 Rte de Mende
34000 Montpellier
giudi@ligm.crbm.cnrs-mop.fr
Database : Maize
Species : Zea mays L. ssp. mays
Focus : Maize genome
Acedb_version : 1.9
FTP : probe.nalusda.gov, pub directory; anonymous ftp
Comment : Maize is an acedb front end for the Maize Genome
Database, MaizeDB, a SYBASE database.
Comment : MaizeDB is updated daily and has WWW connectivity
to external databases: GenBank (loci, alleles and
probes), SwissProt (gene products) and the E. coli
Stock Center (loci).
Data : Major data categories: 4522 mapped loci (located to
chromosome or better) including 684 mapped genes and
1423 mapped probed sites (gene candidates); 982
probes; 1850 map scores; 1533 gel patterns
(Probe/Enzyme/Stock); 4231 stocks; 5105 Variations
(alleles, DNA polymorphisms, rearrangements, etc);
465 phenotypes; 223 traits; 547 gene products;
5314 bibliographic references; 1979 persons with
addresses.
Gopher : host = teosinte.agron.missouri.edu, port = 70
Telnet : telnet teosinte.agron.missouri.edu
login as guest, use password 'corncob'
HTTP : http://teosinte.agron.missouri/top.html
HTTP : http://probe.nalusda.gov:8000/acedbs/index.html
via PGD, the Plant Genome Database
Comment : Genera is a software toolkit for creating and
extracting data from Sybase databases; used to
create MaizeDB and Worldwide Web connectivity.
HTTP : Genera Info http://cgsc.biology.yale.edu/genera.html
Funding : MaizeDB USDA/ARS to E. Coe
Funding : Genera NSF BIR 92-01652 to S. Letovsky and M. Berlyn
Curator/PI : Ed Coe ed@teosinte.agron.missouri.edu
Curator : Pat Byrne byrne@teosinte.agron.missouri.edu
Curator : Georgia Davis gdavis@teosinte.agron.missouri.edu
Curator : Mary Polacco maryp@teosinte.agron.missouri.edu
Curator : Marty Sachs, Maize Stock Center, msachs@uiuc.edu
Curator : Christiane Fauron FAURON@GENE1.med.utah.edu
Curator : Carolyn Wetzel cmwetzel@iastate.edu
Curator : Steve Rodermel S1SRR@ISUVAX.IASTATE.EDU
Design : Stan Letovsky letovsky-stan@CS.YALE.EDU
Design : Mary Berlyn mary@fetalpig.biology.yale.edu
Systems Manager : Denis Hancock
dhancock@teosinte.agron.missouri.edu
Contact : db_request@teosinte.agron.missouri.edu
Last_update : 25 April 1994
Database : MycDB
Species : Mycobacteria
Comment : MycDB is a collation of data on the mycobacteria,
causative agents of tuberculosis and leprosy. It
is centered on the mapping and sequencing projects
under way in M.leprae and M.tuberculosis.
PI : Staffan Bergh
PI : Stewart Cole
PI : Doug Smith
Curator : Staffan Bergh
Contact : staffan@biochem.kth.se
Last_update : Apr. 1994
WWW : http://kiev.physchem.kth.se/MycDB.html
ftp : ftp.pasteur.fr (157.99.64.12) in pub/MycDB
ftp : kiev.physchem.kth.se (130.237.52.64) in pub/MycDB
ftp : bioinformatics.weizmann.ac.il (132.76.55.12) in
pub/databases/mycdb
Database : PomBase
Curator : Sean Walsh
Curator : Marie-Adele Rajendream
PI : Bart Barrell
Species : Schizosaccharomyces pombe
Contact : svw@sanger.ac.uk
Contact : barrell@sanger.ac.uk
Comment : Not yet available for distribution
DataBase : Mousedb
Species : Musculus Musculus
Species : Homo Sapiens
ACEDB_version : 3.0 with extensions to define and display
cytogenetic data.
Description : Mouse genome data from the published literature,
including mouse genes with phenotypic effects, chromosome
anomalies, imprinted regions and man-mouse homologies with
associated pathological disorders. The maps are consensus
ones. They use data, such as the HIS and anomaly data, to
show alignments between the genetic and cytogenetic maps.
Curator : Michelle Kirby
Curator : Rachael Selley
PI : Mary Lyon
PI : Jo Peters
Availability : Mousedb is available publicly from the UK HGMP
Resource Centre's computing service via the INTERNET. For
user id. please contact Administration, HGMP Resource Centre,
Hinxton Hall, Cambridgeshire CB10 1RQ, UK.
Tel: (+44) 1223 494520 Fax: (+44) 1223 494510 For other
information contact Michelle Kirby.
Contact : kirbym@har-rbu.mrc.ac.uk (or mkirby@hgmp.mrc.ac.uk)
rselley@har-rbu.mrc.ac.uk
MRC Radiobiology Unit, Chilton, Didcot, Oxon OX11 ORD
Last_update : October 1994
Database : RiceGenes
Species : Rice (O. sativa)
Availability : Anonymous ftp from probe.nalusda.gov:pub/rice
Availability : Gopher nightshade.cit.cornell.edu port 70
Availability : Gopher probe.nalusda.gov port 7007
Curator : Edie Paul
PI : Susah McCouch
Contact : epaul@nightshade.cit.cornell.edu
Release : ACEDB 1-10
Last_update : May 1994
Database : SacchDB
Species : Saccharomyces cerevisiae
Focus : Budding Yeast Genome
Acedb_version : 2.0, MacAce
FTP : genome-ftp.stanford.edu, not available yet.
Comment : The database is in beta test by a small number of
yeast labs. The WWW-ACEDB gateway version is
currently available, see HTTP below. The Gopher
server contains only the Olson restriction map
information and views of the resulting Clone
(Physical) Map.
Data : Olson/Riles Physical Map, Mortimer Genetic Maps and
Information, Sequences from GenBank, Gene/Clone
associations using the Wash Univ. prime clone
filters.
Gopher : host = genome-gopher.stanford.edu, port = 70
HTTP : URL http://genome-www.stanford.edu
Funding : National Center for Human Genome Research, NIH
PI : David Botstein, botstein@genome.stanford.edu
Project Manager/Curator : Mike Cherry, cherry@genome.stanford.edu
Curator : Fred Dietrich, dietrich@genome.stanford.edu
Curator : Selena Dwight, dwight@genome.stanford.edu
Curator : Cathy Ball, ball@genome.stanford.edu
Systems : Dan Mosedale, mosedale@genome.stanford.edu
Contact : yeast-curator@genome.stanford.edu
Data_Submission : yeast-curator@genome.stanford.edu
Last_update : 9 August 1994
Database : SolGenes
Coverage: Solanaceae - tomato, potato, pepper
Availability : Anonymous ftp from probe.nalusda.gov:pub/solgenes
Availability : Gopher nightshade.cit.cornell.edu port 71
Availability : Gopher probe.nalusda.gov port 7006
Curator : Edie Paul
PI : Steve Tanksley
Contact : epaul@nightshade.cit.cornell.edu
Release : ACEDB 3.0
Last_update : May 1994
Database : SorghumDB
Species : Sorghum bicolor (L.) Moench
PI : Keith F. Schertz
USDA-ARS
Dept. of Soil & Crop Sciences
Texas A&M University
College Station, TX 77843-2474
Phone : (409) 260-9252
FAX : (409) 845-0456
E_mail : schertz@tamvm1.tamu.edu
Curator : Najeeb U. Siddiqui
Southern Crop Improvement Facility
Crop Biotechnology Center
Texas A&M University
College Station, TX 77843-2123
Phone : (409) 862-1523
FAX : (409) 862-4790
E_mail : nus6389@tamsun.tamu.edu
Last_update : July 1994
ACEDB_version : 3.0
Availability : Under Development
Database : SoyBase
Species : Soybeans
Curator : Lisa Lorenzen
PI : Randy Shoemaker
Contact : lorenzen@mendel.agron.iastate.edu
Phone : 515-294-0421
Fax : 515-294-2299
Last_update : Sept. 1993
Database : Sybace
Species : Homo sapiens
Creator : Detlef Wolf
Comment : Custom software --ACEDB front-end to SYBASE data
Contact : D.Wolf@dfkz-heidelberg.de
See_also : IGD
Database : TreeGenes
Species : Forest trees
Availability : alpha, contact curator
ACEDB_version : 1-10
Curator : Bradley K. Sherman
PI : David B. Neale
Contact : Dendrome@s27w007.pswfs.gov
Contact : bks@s27w007.pswfs.gov
Contact : dbn@s27w007.pswfs.gov
Last_update : March 1994
URL : gopher://s27w007.pswfs.gov/
URL : http://s27w007.pswfs.gov/
URL : ftp://probe.nalusda.gov/pub/trees
Database : 21Bdb
Species : Homo sapiens
Focus : STS content mapping & sequencing of Human Chromosome 21
Availability : by request, via ftp, world-wide-web
Based_on : acedb.1-10 plus moulon server
URL : ftp://genome.lbl.gov/pub/21Bdb-v1.1.tar.Z
URL : http://genome.lbl.gov/Genome/acepage.html
Curator : Donn F. Davy
Contact : DFDavy@lbl.gov
Contact : aggarwal@genome.lbl.gov
Focus : STS content mapping & sequencing of Human Chromosome 21
PI : Michael Palazzolo
PI : Chris Martin
PI : Jan-Fang Cheng
Last_update : Apr. 1994
Database : 22ace
Species : Homo sapiens
Curator : Ian Dunham
Focus : Physical mapping of chromosome 22
PI : Ian Dunham
Contact : Ian Dunham
Sanger Centre
Hinxton Hall,
Cambs. UK.
id1@sanger.ac.uk
Database : VoxPop
Species : Populus spp.
Availability : contact curator
Curator : Carl G. Riches
PI : Reinhard F. Stettler
Contact : cgr@poplar1.cfr.washington.edu
Contact : STETTLER@coyote.cfr.washington.edu
Last_update : Sept. 1993
Database : Xace
Species : Homo sapiens
Curator : Gareth Maslen
Focus : Physical mapping of chromosome X
PI : David Bentley
Contact : Gareth Maslen
Sanger Centre
Hinxton Hall,
Cambs. UK.
glm@sanger.ac.uk
Database : ?
Species : Homo sapiens
Focus : Physical mapping of human chromosome 6.
Curator : Ioannis Ragoussis
Availability : Unknown
Contact : Guy's hospital
Database : ?
PI : Scott Chasalow
Species : Potato
Contact : Scottish Crop Institute, Dundee
Last_update : Sept. 1993
Database : ?
PI : George Murphy
PI : David Flanders
Species : Arabidopsis thaliana
Contact : John Innes Center, Norwich, England
Last_update : Sept. 1993
Database : ?
Species : Homo Sapiens
Focus : Physical and linkage mapping of chromosome 8
Availability :
Curator : Stephen Wood
PI : Stephen Wood
Contact : Stephen Wood
Dept. Medical Genetics
University of B. C.
Vancouver, B. C.
Canada
swood@unixg.ubc.cq
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Q5: What written documentation exists for ACEDB?
A5:
From Sam Cartinhour:
The ACEDB Documentation Server is a repository for
documentation concerned with "A C. elegans Data Base",
the generic genome database software designed by
Richard Durbin (MRC, UK) and Jean Thierry-Mieg
(CNRS, France). The server is intended as a resource
for developers, curators, and end-users of all (not
just plant) databases derived from ace. Eventually
we hope to offer all kinds of documentation, from
reprints to (technical) gossip. The ACEDB
documentation server is sponsored by the Plant Genome
Database Project at the National Agricultural Library
(USDA). The documentation server is listed on the
home page for the Agricultural Genome World Wide Web
Server at http://probe.nalusda.gov:8000.
Primary documents from the developers are:
acedb -- A C. elegans Database: I. Users' Guide.
acedb -- A C. elegans Database: II. Installation Guide.
acedb -- A C. elegans Database: III. Configuration Guide.
Syntactic Definitions for the ACEDB Data Base Manager
--Jean Thierry-Mieg and Richard Durbin (1991-)
Get By anonymous ftp from ncbi.nlm.nih.gov (130.14.20.1)
in repository/acedb:
ftp://ncbi.nlm.nih.gov/respository/acedb/doc*tar.Z
And ftp://weeds.mgh.harvard.edu/acedb_doc
The files are in tex and postscript. [I have had
some difficulty printing these. Jean Thierry-Mieg
suggests latex xxxx.tex, dvi2ps xxxx.dvi > xxxx.ps,
lpr xxxx.ps.]
You will find interesting documents in the wdoc
subdirectory of the ACEDB distribution.
The Australian National Genomic Information Service has prepared
good documentation of the C. elegans version as
Angisturte.ps and angistute.hqx
available by anonymous ftp at ncbi.hih.gov in repository/acedb/ace2.
Cherry, J.M., Cartinhour, S.W., and Goodman, H.M. (1992) AAtDB,
An Arabidopsis thaliana Database. Plant Molecular Biology Reporter
10 (4): 308-309,409-410
Tutorial manual for AAtDB:
Cartinhour, S., Cherry, J.M., and Goodman, H.M. (1992) An
Introduction to ACeDB: For AAtDB, An Arabidopsis thaliana
Database. Massachusetts General Hospital. (Available on
request in printed form from the AAtDB curator).
A description of ACEDB:
Cherry, J.M. and Cartinhour, S.W. (1994) ACEDB, A tool for
biological information. in Automated DNA Sequencing and
Analysis, edited by M. Adams, C. Fields, and C. Venter.
Academic Press, pages 347-356. [text is available through
ftp or gopher from weeds.mgh.harvard.edu]
Another description of ACEDB for physical mapping projects:
Dunham, I., Durbin, R., Mieg, J-T & Bentley, D.R. (1994)
Physical mapping projects and ACEDB, in Guide to Human
Genome Computing. Ed. Bishop, M.J. Academic Press,
pages 111-158. [text is available through ftp or
gopher from weeds.mgh.harvard.edu]
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Q6: Where can I find further information about ACEDB?
A6: There is a Usenet/Biosci conference titled bionet.software.acedb.
If you do not have access to the Biosci conferences via a
newsreader (e.g. rn, trn, tin) you can participate in the conference
by electronic mail. To subscribe to the e-mail version of the
conference send email to biosci-server@net.bio.net (UK, European
readers use biosci@uk.ac.daresbury or biosci.daresbury.ac.uk) with
no subject line and only the message
subscribe ACEDB-SOFT
in the body. To unsubscribe send the message
unsubscribe ACEDB-SOFT
to the same address.
This is an automated service. Your e-mail address will be taken
from the header of the message that you send. If you then send
mail to acedb@net.bio.net the mail will be distributed to all
subscribers and to the electronic conference.
All of the articles are archived on the gopher at net.bio.net.
Mike Cherry has set up an ACEDB Developer's archive. For
anonymous ftp use the hostname weeds.mgh.harvard.edu and look in
the acedb_dev directory. If you wish to contribute you can put
files in the incoming directory. Send a message to Mike
(cherry@genome.stanford.edu) that you have put something in that
directory then Mike will move it out for general access.
For gopher you can connect to weeds.mgh.harvard.edu
(132.183.190.21) and ...
--> N. FTP Archives for Molecular Biology/
then
--> M. ACEDB Developer's archive/
[N and M are integers which are subject to change.]
The bionet.software. acedb.conference is archived and can be
searched using WAIS. Here is a Gopher-style link to the WAIS
archive. (This is also courtesy of Mike Cherry.):
#
Type=7
Name=ACEDB BioSci Electronic Conference
Path=7/.index/acedb-biosci
Host=genome-gopher.stanford.edu
Port=70
The AAtDB, Soybase, GrainGenes, Mace, and TreeGenes [see Q4]
databases regularly submit data to the Plant Genome Database
at the National Agricultural Library (NAL). Nal makes this
data available via the WWW using an http server with URL:
http://probe.nalusda.gov:8000/index.html
You will also find a selection of models.wrm files (schemata)
for the various databases here. You will want to get a
"mosaic client" to examine this.
AboutDB is a stab at an integrated info and project tracking database
for the 'Greater ACEDB Community'. It was conceived and implemented by
Staffan Bergh (staffan@biochem.kth.se), the 'coordinator', during the
ace94 workshop in Montpellier, based on an earlier effort by John
McCarthy. The aim is to collect information on all aspects of ACEDB
use as a database manager. Currently it contains information on
Databases implemented in ACEDB, Colleagues in the community, some
Tools for >curators of ACEDB databases and some of the information
on 'magic tags' collected during the ace94 workshop.
AboutDB can be reached at URL: http://kiev.physchem.kth.se/AboutDB.html
Other URL's that readers with mosaic clients might want to
examine are:
http://moulon.inra.fr/acedb/acedb.html for C. elegans data
http://kiev.physchem.kth.se/MycDB.html for Mycobacterium data
http://moulon.inra.fr:8001/acedb/igd.html for an integrated
genome database.
For information on how these were created see
http://moulon.inra.fr/acedb_conf_eng.html
http://moulon.inra.fr/acedb_conf.html (en francais)
The Genome Computing Group, Lawrence Berkeley Laboratory
has an anonymous ftp service at machine genome.lbl.gov
(131.243.224.80) which contains:
flydb - LBL's Drosophila Acedb-style database
21bdb - LBL's Human Chromosome 21 Acedb-style database
querdb - LBL's query-language extensions to Acedb
metadata - LBL's compendium of Acedb database schema variants
macace-aatdb-demo.hqx - pre-release Acedb MacIntosh version
There is also a repository of contributed software for
data conversions and the like.
[From Otto Ritter]
IGD - the Integrated Genomic Database - is an international
project of DKFZ, Heidelberg (Germany), CNRS, Montpellier
(France), ICRF, London (UK), LBL, Berkeley (USA), and MRC,
London/Cambridge, (UK). IGD is an extensible object-oriented
distributed information management system with one global schema,
physical data integration at the back-end, and local data
management at the front-end. It supports local schema evolution
and local data integration, and has a potential for truly virtual
"on-the-fly" integration (federation) of its resource databases.
Beside data integration, IGD provides graphical user interface,
client/server communication, and seamless interface to a growing
number of tools for structure, sequence, genetic, physical and
comparative mapping analysis. ACEDB is the IGD main software
component for data management. As a database, IGD integrates
and references genome related data from public sources. As an
analysis tool, IGD provides uniform interface to existing
programs and program packages for tructure and sequence
analysis, genetic and physical map construction and analysis,
etc. In addition to the major human and mouse databases already
planned SWISS-PROT/PIR, PDB, GDB, OMIM, CitDB, CEPH, CHLC,
CEPH-Genethon, Genbase, UK DNA ProbeBank, RLDB2, CAD, MGD,
MouseBackcross DB), crossreferences will be maintained to
dataabases established around specific model organisms
(C.elegans, D. melanogaster, S. cerevisiae, pombe etc.).
Refs:
1/ Ritter,O.: The Integrated Genomic Database. in Computational
Methods in Genome Research, edited by S.Suhai, Plenum,
57-73 (1994).
2/ Ritter,O., Kocab,P., Senger,M., Wolf,D., and Suhai,S.:
Prototype Implementation of the Integrated Genomic
Database, Computers and Biomedical Research, 27, 97-115 (1994)
Computer staff for the UC Berkeley Drosophila physical mapping
project the LBL Human Chromosome 21 project, and the LBL plant
genome projects meet regularly to coordinate their ACEDB
extension and development efforts, along with Frank Eeckman,
who is working on the Macintosh version of ACEDB (for further
information, contact jlmccarthy@lbl.gov). They also keep in
close touch (via email, personal visits, etc.) with their
counterparts in Cambridge (Richard Durbin et al), Montpellier
Jean Thierry-Mieg et al), and the Interated Genome Database
project in Heidelburg (Otto Ritter, Detlef Wolf et al).
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Q7: How should ACEDB be cited?
A7: From the distribution:
We realize that we have not yet published any "real" paper on
ACEDB. We consider however that anonymous ftp servers are a
form of publication. We would appreciate if users of ACEDB
could quote:
Richard Durbin and Jean Thierry Mieg (1991-). A C. elegans
Database. Documentation, code and data available from
anonymous FTP servers at lirmm.lirmm.fr,
cele.mrc-lmb.cam.ac.uk and ncbi.nlm.nih.gov.
Papers involved in database development could quote more
precisely:
I. Users' Guide. Included as part of the ACEDB distribution
kit,
II. Installation Guide. Included as part of the ACEDB
distribution
III. Configuration Guide. Included as part of the ACEDB
distribution
and the preprintkit, available by Anonymous FTP from ...
Jean Thierry-Mieg and Richard Durbin (1992). Syntactic
Definitions for the ACEDB Data Base Manager. Included as
part of the ACEDB distribution.
--Jean and Richard.
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Q8: Is ACEDB object-oriented?
A8: From the ACEDB User's Guide.
A major current vogue in computer languages and database design
is for ``object-oriented'' systems. It's also a source of lots
of argument. We are just trying to build a good system, and
don't want to get caught in the crossfire, but we do talk about
organising our data into objects and classes. We have undoubtedly
been influenced by many of the ideas going around, but it isn't
likely our system would be regarded as kosher by the object-
oriented community. In particular there is no class hierarchy, nor
inheritance, and it is written in a modular but non-ideological way
in straight C. However display and disk storage methods are class
dependent.
In some ways the class hierarchy is replaced by our system of
models and trees, which seems to be rather unusual. We think it
is very natural for the representation of biological information,
where for some members of a class a lot might be known about some
aspect, but for most only a little is known.
The advantages of our sytem over a relational database, such as
Oracle or Sybase, is our ability to refine our descriptions without
rebuilding the database and the possibility of organising the
storage of data on disk according to their class, i.e. we store in
a very different way the tree-objects and the long stretches of
DNA sequence.
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Q9: What's all this about Gopher/WAIS/ftp/WWW ...
A9: These terms all refer to Internet protocols.
An excellent introduction to the Internet is:
_The Whole Internet User's Guide & Catalog_,
by Ed Krol, O'Reilly & Associates, 1992.
Or ask your system administrator to provide you with
a gopher client or mosaic client and begin navigating
on your own.
URL is a Universal Resource Locator on the World-Wide
Web (WWW). There are many free Internet browsers
available that allow you to use an Internet connection
and a URL to access services. Mosaic may be the
most popular and it is available for Mac, PC or Unix
via anonymous ftp from ftp.ncsa.uiuc.edu.
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Q10: How can I get on/off the ACEDB announcements mailing list?
A10: To get on or off the mailing list send mail to
rd@mrc-lmb.cam.ac.uk or mieg@kaa.crbm.cnrs-mop.fr.
New releases of the software are announced to this
list and very little else. The BIOSCI newsgroup
bionet.software.acedb is on the mailing list.
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Q11: When and where is the Next ACEDB Workshop?
In planning, California 1995.
[Contact information to appear here. --bks]
If you would like to see some pictures of the
ACEDB '94 Workshop in St. Matthieu de Treviers taken by Mike
Cherry with the camera on an SGI workstation, the URL is:
http://genome-www.stanford.edu/~cherry/pics/acedb-94.pics.html.
John Morris has provided some more at URL:
http://weeds.mgh.harvard.edu/ace94/ace94.image.html.
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Q411:Who prepared this document & where is the current version?
[Note to international readers: 411 is the phone number for
information in the USA. --bks]
This document will be posted monthly to the BIOSCI newsgroup
bionet.software.acedb and to USENET conference news.answers.
It is intended to be used as an index to ACEDB databases and
to information about the database software.
The latest text version of the ACEDB FAQ should be available via
anonymous ftp at machine
net.bio.net
as file
pub/BIOSCI/ACEDB/ACEDB.FAQ or at
rtfm.mit.edu as pub/usenet/news.answers/acedb-faq. Answer 3
demonstrates a sample FTP session. If you only have
electronic mail, the FAQ can be retrieved from
mail-server@rtfm.mit.edu.
There is an HyperText Markup Language (HTML) version of this
document available on the World Wide Web:
http://probe.nalusda.gov:8000/acedocs/acedbfaq.html
http://s27w007.pswfs.gov/Homepage/acedbfaq.html
Curators of ACEDB databases should take note of Question 4 and
keep me apprised of changes.
Errors of commission or omission are unintentional. If I have
forgotten to give you credit please let me know. Please
send comments and corrections to: acedbfaq@s27w007.pswfs.gov
Major contributions in getting this FAQ off the ground
were made by John McCarthy and Mike Cherry. Other
contributors include:
Lisa Lorenzen
David Matthews
Edie Paul
Donn Davy
Eric De Mund
Sam Cartinhour
Please cite as:
Sherman,B.K., ACEDB Genome Database Software FAQ,
ftp://rtfm.mit.edu/pub/usenet/news.answers/acedb-faq,
http://probe.nalusda.gov:8000/acedocs/acedbfaq.html,
1993,1994, approx. 50K bytes.
To add or modify information in this document, please
send mail to: acedbfaq@s27w007.pswfs.gov
Bradley K. Sherman
Dendrome Project
Institute of Forest Genetics
P.O. Box 245, Berkeley, CA, 94701
Phone: 510-559-6437 Fax: 510-559-6440
The Dendrome Project and TreeGenes are funded by the
USDA ARS Plant Genome Research Program.
--bks
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